AZD 5438
- Product Name
- AZD 5438
- CAS No.
- 602306-29-6
- Chemical Name
- AZD 5438
- Synonyms
- AZD;CS-1903;AZD 5438;AZD5438, >=98%;AZD 5438; AZD5438;AZD 5438 USP/EP/BP;AZD5438 >=97% (HPLC);4-[2-Methyl-1-(1-Methylethyl)-1H-iMidazol-5-yl]-N-[4-(Methylsulfonyl)phenyl]-;4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine;4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
- CBNumber
- CB61512498
- Molecular Formula
- C18H21N5O2S
- Formula Weight
- 371.46
- MOL File
- 602306-29-6.mol
AZD 5438 Property
- Boiling point:
- 655.2±65.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥42.1 mg/mL in EtOH
- form
- solid
- pka
- 4.08±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- SML1855
- Product name
- AZD5438
- Purity
- ≥97% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2024/03/01
- Product number
- SML1855
- Product name
- AZD5438
- Purity
- ≥97% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2024/03/01
- Product number
- 21598
- Product name
- AZD 5438
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 21598
- Product name
- AZD 5438
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 21598
- Product name
- AZD 5438
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $374
- Updated
- 2024/03/01
AZD 5438 Chemical Properties,Usage,Production
Uses
AZD 5438 is a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, which leads to leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
Definition
ChEBI: 4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine is a sulfonamide.
Biological Activity
azd5438 is a potent small molecule inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 with half maximal inhibitory concentration ic50 of 16 nmol/l, 6 nmol/l and 20 nmol/l respectively. azd5438 has also been found to potently inhibit the human cyclin e/cdk2 complex, the cyclin b1/cdk1 complex and the cyclin a/cdk2 complex with ic50 of 0.006 μm, 0.016 μm and 0.045 μm respectively. in previous studies, azd5438 has exhibited significant anti-proliferative activity in a few human tumor cell lines with ic50 ranging from 0.2 μmol/l to 1.7 μmol/l, in which the phosphorylation of a few proteins, including cdk substrates prb, nucleolin, protein phosphatase 1a and rna polymerase ii cooh-terminal domain, and cell cycling at g2-m, s and g1 phases were inhibited.
storage
Desiccate at RT
References
[1]camidge dr1, smethurst d, growcott j, barrass nc, foster jr, febbraro s, swaisland h, hughes a. a first-in-man phase i tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor azd5438 in healthy male volunteers. cancer chemother pharmacol. 2007 aug;60(3):391-8. epub 2006 nov 18.
[2]byth kf, thomas a, hughes g, forder c, mcgregor a, geh c, oakes s, green c, walker m, newcombe n, green s, growcott j, barker a, wilkinson rw. azd5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. mol cancer ther. 2009 jul;8(7):1856-66. doi: 10.1158/1535-7163.mct-08-0836. epub 2009 jun 9.
AZD 5438 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD 5438 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
View Lastest Price from AZD 5438 manufacturers
- Product
- AZD 5438 602306-29-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25